Biomedical Engineering Reference
In-Depth Information
Table 5.1
Comparison of Characteristic Features of Various Viral Vectors
Name of Vector
Major Advantage(s)
Major Obstacle(s)
Insert Size
Integrate
Titer
Transduction
Efficiency
10
12
Adenovirus
It can transfect in nearly
all cell types, dividing or
nondividing cells
Transient expression triggers
immune response, common
human virus
7.5 kb
No
High
10
6
Adeno-associated
viral vectors (AAV)
Transfection is stable
Small insert size, integration
poorly understood
4 kb
Yes
High
10
10
Herpes simplex viral
vectors (HSV)
Large insert size, neuron
specificity
Transient expression, potential
to generate infectious HSV in
humans
20 kb
No
Low
10
6
Moloney Murine
Leukemia viral
(MMLV) vectors
Transfection of dividing
cells is stable
It can infect only rapidly dividing
cells
8 kb
Yes
High
Vaccinia
It can infect a variety of
cells effectively
Limited to nonsmall
pox vaccinated or
immunocompromised individuals
25 kb
No
N/A
High
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