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CH
3
H
2
N
N
HN
HN
O
O
CH
3
NH
NH
2
DOGS
H
3
C
CH
3
CH
3
CH
3
H
3
C
CH
3
O
N
H
3
C
N
H
O
DC-Chol
O
O
CH
2
H
2
N
N
N
H
N
H
H
HN
CH
2
O
pcTG37
H
2
N
O
O
CH
2
N
H
N
HN
CH
2
O
NH
2
pcTG89
Figure 4.12
Chemical structures of lipoamines I.
in combination with DOPE (
Fig. 4.12
)
[220]
. These compounds demonstrated effi-
cient transfection against dog myoblast and human pulmonary epithelial carcinoma
A549 cells
in vitro
and C57BL/6 mice
in vivo
. The physiochemical properties of
complexes either alone or in combination play a significant role for their transfection
activity. It was observed that complete complexation of DNA and small diameters of
complexes are favorable for their biological activity. Later, penta-ammonio analogue
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