Evaluation of Unconventional Protein Secretion in Saccharomyces cerevisiae - Membrane Trafficking - page 56

Table 1
(continued)

SNARE protein-
coding genes

Essential or
nonessential Pathway Description

10 TGN to LE PEP12 Nonessential Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the

Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde
traffi c into the prevacuolar compartment; Syntaxin

VTI1 Essential -

SYN8 Nonessential Endosomal SNARE related to mammalian syntaxin 8

11 CM to EE SYN8 Nonessential -

SNC1/2 Nonessential -

12 LE to V VTI1 Essential -

VAM7 Nonessential -

13 LE to MVB

14 MVB to V

15

MVB to
Amphisome

16 ER to A

17 Amphisome to
CM
Under line: Unessential. Bold: Used in several pathways. Descriptions are modifi ed from Saccharomyces Genome Database (SGD, http://www.yeastgenome.org/ )
N nucleus, ER endoplasmic reticulum, TGN trans -Golgi network, V vacuole, EE early endosome, LE late endosome, MVB multivesicular body, A autophagosome, CM cell
membrane