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(a)
170
160
150
140
130
120
110
ppm
(b)
170
160
150
140
130
120
110
ppm
(a)
Pyruvate C
1
Lactate
C
1
Pyruvate C
1
(hydrate)
Alanine C
1
200
190
180
170
160
PPM
(b)
Figure5.6
(Left)
13
CNMRspectraat9.4Tandroomtemperatureof(A)urea(59.6mMinwater)hyperpolarized
by the DNP-NMR method and (B) urea (59.6mM in water) at thermal equilibrium (acquisition time: 65h)
(Reprinted from [285], Copyright2003, with permission from National Academy of Sciences, U.S.A.)
285
(Right)
In vivo metabolicproduction of lactateand alanineafterthe injectionof hyperpolarized
13
C
1
pyruvatein a rat.
13
C NMR spectra were acquired with a time interval of 3 s at 1.5T on a clinical MRI. (Reprinted from [286],
Copyright2003,withpermissionfromNationalAcademyofSciences,U.S.A.)
286
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