Chemistry Reference
In-Depth Information
Disaccharides
R
1
O
O(CH
2
)
7
CH
3
R
1
O
O(CH
2
)
7
CH
3
O
O
R
1
O
R
2
O
O
O
OR
1
OR
1
R
2
O
O
R
1
O
R
2
O
O
R
1
R
2
R
1
R
2
OR
2
18
19
20
21
R
2
O
R
2
O
Me
Bn
Me
H
Ac
H
H
H
22
23
2
25
26
Bn
Me
Bn
Me
H
Ac
Ac
H
H
H
OR
2
R
2
O
Iminosugars
OH
O
H
HO
HO
O
H
O
H
NH
NH
H
HO
HO
NH
NH
HO
HO
27
29
H
HO
HO
30
28
Nucleotide-furanoses
O
HO
O
31
:R=CH
2
F(6-F-
α
-
D
-Gal
f
)
32
:R=H(
β
-
L
-Ara
f
)
33
:R=CH
3
(
α
-
D
-Fuc
f
)
NH
O
O
HO
O
O
O
P
P
R
OH
N
O
O
O
O
O
HO
O
OH
OH
NH
O
O
OH
O
O
O
P
P
N
O
O
HO
O
O
34
(5d-
α
-D-G al
f
)
OH
OH
Fig. 4 Some furanosyl-containing compounds study on membrane extracts.
Inhibitors of both GlfT1 and GlfT2
HO
O
HO
O
O
O
O
O
O
HO
OH
O
O
HO
O
P
UMP
O
O
P
UMP
OH
P
UMP
HO
O
O
HO
34
O
32
β
OH
33
β
Inhibitors of GlfT1
HO
HO
O
O
O
O
HO
HO
OH
O
O
O
O
P
UMP
P
UMP
OH
F
O
O
33
α
31
α
Non inhibitors
O
O
O
O
O
HO
HO
O
HO
P
UMP
O
P
UMP
O
O
O
O
HO
HO
O
HO
UMP
OH
OH
OH
F
F
35
32
α
31
α
Fig. 5 Properties of some UDP-furanoses.
Another test was also developed, even if it does not give mechanistic
information, but simply data on the bactericidal or bacteriostatic prop-
erties of the tested compounds. It relies on the measurement of the
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