Biomedical Engineering Reference
In-Depth Information
Table 5.1 (continued)
microRNA
Reported in
CHO
Affected pathway
Effect type
Target(s)
miR-124a
No
Metabolism
Regulation of glucose
metabolism
?
Promotes protein secretion
Rab27A
miR-125b
Yes
Cell growth
Promotes growth
?
miR-133
No
Cell growth
Promotes growth
SRF
miR-143
Yes
Cell growth
Growth inhibitory
ERK5
miR-146a/b
Yes
Protein secretion
Restrains protein secretion
NF
B, IRAK1,
TRAF6
κ
miR-148
Yes
Apoptosis
Anti-apoptotic
?
miR-144@
miR451
Yes
Oxidative stress
Protection against oxidative
stress
Nrf2
ξ
14-3-3
miR-204
Yes
Apoptosis
Anti/pro-apoptotic
Bcl2l2, BIRC2,
EZR, M6PR,
SERP1
ER and oxidative
stress
Stress induction
M6PR
miR-200b
Yes
Osmotic stress
Inhibition of stress
response
OREBP
miR-210
Yes
Apoptosis
Anti-apoptotic
?
Hypoxia
Decrease pro-apoptotic
signals during hypoxia
Ephrin-A3
miR-214
Yes
Apoptosis
Pro-apoptotic
?
miR-216
No
Apoptosis
Anti-apoptotic
?
miR-218
Yes
Apoptosis
Pro-apoptotic
ECOP
miR-221@
miR222
Yes
Cell growth
Growth inhibitory
Kit
ER stress
Increased ER
stress-induced apoptosis
?
miR-296
Yes
Apoptosis
Anti-apoptotic
?
Metabolism
Regulation of glucose
metabolism
?
miR-372@
miR-373
No
Cell growth
Promotes growth
LATS2
miR-375
No
Metabolism
Regulation of glucose
metabolism
Mtpn, PDK-1
Protein secretion
Inhibits protein secretion
?
γ
miR-378*
Yes
Metabolism
Reduced activity of TCA
cycle
ERR
, GABPA
miR-466h
Yes
Apoptosis
Pro-apoptotic
Bcl2l2, Dad1,
BIRC6, Stat5a,
Smo
miR-484
Yes
Metabolism
Regulation of glucose
metabolism
?
miR-690
No
Metabolism
Regulation of glucose
metabolism
?
miR-708 Yes ER stress Improve protein folding RHO
miR-717 No Osmotic stress Inhibition of stress response OREBP
miRs effects on industrially-relevant pathways and their respective targets. (@) indicates combines
miRs with the same effect on the pathway and same targets, (?) indicates unknown miR targets in
relation to specific pathways
 
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