Image Processing Reference
In-Depth Information
19
Assessment of Cerebral
Blood Flow, Volume,
and Mean Transit Time
from Bolus-Tracking
MRI Images: Theory
and Practice
Alessandra Bertoldo, Francesca Zanderigo,
and Claudio Cobelli
CONTENTS
19.1 Introduction............................................................................................587
19.2 Theory ....................................................................................................588
19.2.1 Transport Function ..................................................................588
19.2.2 Residue Function.....................................................................589
19.2.3 Cerebral Blood Volume...........................................................589
19.2.4 Mean Transit Time ..................................................................591
19.2.5 Cerebral Blood Flow...............................................................591
19.3 Practice...................................................................................................593
19.3.1 From DSC-MRI Signal
to Tracer Concentration ..........................................................593
19.3.2 Arterial Input Function ...........................................................594
19.3.3 Deconvolution .........................................................................596
19.3.4 Absolute Quantification Issues ...............................................599
19.3.5 Conclusion...............................................................................601
Acknowledgments .............................................................................................601
References .........................................................................................................601
587
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