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chemoselectively, regardless of their reduction
potentials (
Eq. 6.25
). To perform
chemoselective cathodic reduction, the authors
employed a liquid-liquid parallel laminar flow
formed in an electrochemical microflow
reactor. As shown in
Figure 6.30
, when two
solutions (allylic chloride solution and aldehyde
solution) are introduced through inlets 1 and 2
of the microflow reactor, a stable liquid-liquid
interface is formed and mass transfer between
the input streams occurs only by means of
diffusion. The substrate introduced through
inlet 1 can therefore be predominantly reduced,
whereas the reduction of the inlet 2 substrate
(inflow 2) can be avoided. Consequently,
chemoselective cathodic reduction proceeds
and an intentional cross-coupling product is
obtained regioselectively. In other words,
product selectivity control is realized by simply
switching the reagent flows.
(6.25)
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