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section 6.8). This method makes it possible not
only to survey short-life intermediates
generated electrochemically but also to realize
the combinatorial synthesis of useful materials.
6.6 Template-Directed Methods
In general, a regioselective intermolecular
coupling reaction is difficult compared to an
intramolecular one. Template-directed
reactions via intramolecular reactions enable
selective coupling reactions that are otherwise
difficult to achieve. As shown in Figure 6.4 ,
regioselective anodic coupling of phenols can be
achieved using a boron template [18]. First, the
template, tetraphenoxyborate, is prepared in a
one-pot-procedure and then its anodic
oxidation followed by hydrolysis provides an
ortho-ortho coupled product selectively.
(6.4)
A silicon template is also known [19].
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