Chemistry Reference
In-Depth Information
The selectivity of fluorination is also strongly
influenced by supporting fluoride salts, as
shown in
Eq. 5.27
[80]. Since Et
3
N-3HF
contains the free base Et
3
N, the difluorinated
product, once formed, is dehydrofluorinated to
the monofluoro product.
(5.27)
Furthermore, anodic difluorination
accompanied by C-C double bond cleavage is
also known, as shown in
Eq. 5.28
[81].
(5.28)
Anodic fluorination of heterocyclic compounds
derived from optically active α-amino acids
proceeds in good yields and with high
diastereoselectivity, as shown in
Eqs. 5.29
and
5.30
. Notably, fluorination does not occur at the
benzylic position and fluorination
predominantly takes place α to the carbonyl
group, as shown in
Eq. 5.31
[82].
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