Chemistry Reference
In-Depth Information
Generally, it is quite difficult to generate the
enolate anion with an α-CF 3 group since the
enolate anion readily undergoes decomposition
such as β-elimination of fluoride ion. However,
pyrrolidone-derived EGB enables the
generation of stable trifluoromethylated enolate
anion, and alkylation can be performed in good
yield without elimination of the fluorine atom,
as shown in Eq. 5.8 [23].
(5.8)
Furthermore, this EGB catalyzes ring-opening
polymerization of N-carboxyanhydrides of
α-amino acid (NCA) to provide poly(amino
acids) in a short time in excellent yield, as
shown in Eq. 5.9 . The yield is much higher and
the reaction time relatively short compared to
reactions using conventional base with a metal
cation such as Na + [24].
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