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negative potential, −1.5 V vs. SCE, to generate
an alkyl radical or anion, and Co(I) complex is
regenerated simultaneously (reductive
elimination). Since the resulting alkyl radical or
anion undergoes conjugate addition, efficient
Michael addition can be achieved under neutral
conditions, as shown in
Figure 5.4
[12]. This
mediatory reaction is widely applicable to
various halogeno compounds, such as allyl
halides, vinyl halides, α-halo ethers and so on.
Figure 5.4
Electrosynthesis using Co(III)
complex, vitamin B
12
as mediator
As shown in
Eq. 5.5
, even halogeno compounds
with non-protected hydroxyl and carbonyl
groups can be used, which is one of the
advantages of this mediatory system [13].
(5.5)
On the other hand, β-bromodiester and
ω-bromoalkyl
acrylate
undergo
1,2-rearrangement
and
intramolecular
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