Biology Reference
In-Depth Information
CHAPTER THREE
Mechanisms Underlying the
Initiation and Dynamics of
Neuronal Filopodia: From Neurite
Formation to Synaptogenesis
Gianluca Gallo 1
Shriners Hospitals Pediatric Research Center, Center for Neural Repair and Rehabilitation, Department of
Anatomy and Cell Biology, Temple University, Philadelphia, PA, USA
1 Corresponding author: E-mail: gianluca.gallo@temple.edu
Contents
1. Introduction
96
2. RolesofFilopodiaintheDevelopmentofNeuronalMorphogenesisandCircuit
Formation
99
2.1. InitiationofAxonsandDendrites
99
2.2. ExtensionandGuidanceofAxonsandDendrites
103
2.3. FormationofAxonCollateralBranchesandDendriteBranches
107
2.4. FormationofSynapticStructures
109
3. MolecularandUltrastructuralOrganizationofFilopodia
110
3.1. Filopodia:IdenticalTwinsorCousins?
110
3.2. SubilopodialLocalizationofProteins
113
3.3. IntrailopodialTraic
119
3.4. LocalizedProteinSynthesisandRegulationofFilopodia
121
3.5. FilopodiaasSignalingDomains
122
3.6. BiomechanicsofFilopodia
123
4. Initiation,ElongationandRetractionofNeuronalFilopodia
125
4.1. DeterminationoftheSitesofFilopodiaFormation
125
4.2. ActinNucleationandReorganizationduringtheInitiationof
NeuronalFilopodia
131
4.3. Polymerization,DeploymerizationandRetrogradeFlowofActin
FilamentsinFilopodia
135
4.4. RetractionandStabilizationofFilopodia
137
5. Filopodia:LinkingtheActinandMicrotubuleCytoskeleton
139
5.1. ConcertedDynamicsandOrganizationoftheNeuronalMicrotubule
andActinCytoskeleton
139
5.2. ActinandMicrotubulesinFilopodia-MediatedGrowthConeGuidance
139
5.3. ActinandMicrotubulesintheFormationofAxonCollateralBranches
143
6. ConcludingRemarks
145
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