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to be done in order to get a clear understanding of the communication
between TAMs and tumor cells or other types of stromal cells, and how
such communication processes contribute to TAM “re-education.” In the
meanwhile, more molecules that induce angiogenesis inhibition and ves-
sel normalization by skewing TAMs toward M1 phenotype, as well as the
mechanistic basis of these processes, need to be identified. Identifying the
key elements in these anticancer therapeutic strategies will be the main
challenge in the future.
ACKNOWLEDGMENTS
This work was supported in part by the Fondazione Cariparo and the University of Padova.
DISCLOSURE OF POTENTIAL CONFLICTS OF INTEREST
The authors declare that they have no financial interests.
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