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Table 1.1 Genes and molecules differentially expressed in M1 and M2 phenotype macrophages
Highly expressed genes and
molecules in M1 macrophages
Membrane receptors
IL2RA , IL15RA ( Martinez et al., 2006 ); TLR2, TLR4,
CD16, CD32, CD64, CD80, CD86, IL-1R type I, CCR7
( Mantovani et al., 2002 )
Cytokines and growth factors
IL15 , ECGF1 ( Martinez et al., 2006 ); TNF-α, IL-1, IL-6,
IL-12 and IFN-γ ( Mantovani et al., 2002 )
Chemokines
CCL15 , CCL19 , CCL20 ( Martinez et al., 2006 ); CXCL8,
CXCL9, CXCL10, CXCL11, CCL2, CCL3, CCL4,
CCL5 ( Mantovani et al., 2002 )
Effector molecules
iNOS, ROI ( Mantovani et al., 2002 )
Highly expressed genes and
molecules in M2 macrophages
Membrane receptors
CD209 , CD36 , MS4A4A , MS4A6A TLR5 , CLECSF13 ,
TGFBR2 , CXCR4 ( Martinez et al., 2006 ); Scavenger
receptor A/B, CD163, CD206, CD14, CD23, IL-1R
type II, IL7R, CCR2, CXCR1 and CXCR2 ( Mantovani
et al., 2002 )
Cytokines and growth factors
IGF1 ( Martinez et al., 2006 ); IL-1ra, IL-10, IL-4 and IL-13
( Mantovani et al., 2002 ); MSF ( Solinas et al., 2010 )
Chemokines
CCL13 , CCL23 ( Martinez et al., 2006 ); CCL17, CCL22,
CCL24, CCL16 and CCL18 ( Mantovani et al., 2002 )
Effector molecules
Arginase I ( Mantovani et al., 2002 )
CLECSF13 , C-type lectin superfamily member 13; ECGF1 , endothelial cell growth factor 1; IGF1 , insulin-like growth factor 1; IL2RA , interleukin 2 receptor α
chain; MS4A4A , membrane-spanning 4-domains, subfamily A, member 4A; TGFBR2 , transforming growth factor-beta (TGF-β) receptor type 2.
CCR7, chemokine (C-C motif) receptor; CXCL8, chemokine CXC motif ligand 8; CXCR1, C-X-C chemokine receptor 1; IL-1R type I, interleukin 1 receptor
type I; ROI, reactive oxygen intermediates; TLR2, Toll-like receptor 2.
 
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