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Table 1.1
Genes and molecules differentially expressed in M1 and M2 phenotype macrophages
Highly expressed genes and
molecules in M1 macrophages
Membrane receptors
IL2RA
,
IL15RA
(
Martinez et al., 2006
); TLR2, TLR4,
CD16, CD32, CD64, CD80, CD86, IL-1R type I, CCR7
(
Mantovani et al., 2002
)
Cytokines and growth factors
IL15
,
ECGF1
(
Martinez et al., 2006
); TNF-α, IL-1, IL-6,
IL-12 and IFN-γ (
Mantovani et al., 2002
)
Chemokines
CCL15
,
CCL19
,
CCL20
(
Martinez et al., 2006
); CXCL8,
CXCL9, CXCL10, CXCL11, CCL2, CCL3, CCL4,
CCL5 (
Mantovani et al., 2002
)
Effector molecules
iNOS, ROI (
Mantovani et al., 2002
)
Highly expressed genes and
molecules in M2 macrophages
Membrane receptors
CD209
,
CD36
,
MS4A4A
,
MS4A6A TLR5
,
CLECSF13
,
TGFBR2
,
CXCR4
(
Martinez et al., 2006
); Scavenger
receptor A/B, CD163, CD206, CD14, CD23, IL-1R
type II, IL7R, CCR2, CXCR1 and CXCR2 (
Mantovani
et al., 2002
)
Cytokines and growth factors
IGF1
(
Martinez et al., 2006
); IL-1ra, IL-10, IL-4 and IL-13
(
Mantovani et al., 2002
); MSF (
Solinas et al., 2010
)
Chemokines
CCL13
,
CCL23
(
Martinez et al., 2006
); CCL17, CCL22,
CCL24, CCL16 and CCL18 (
Mantovani et al., 2002
)
Effector molecules
Arginase I (
Mantovani et al., 2002
)
CLECSF13
, C-type lectin superfamily member 13;
ECGF1
, endothelial cell growth factor 1;
IGF1
, insulin-like growth factor 1;
IL2RA
, interleukin 2 receptor α
chain;
MS4A4A
, membrane-spanning 4-domains, subfamily A, member 4A;
TGFBR2
, transforming growth factor-beta (TGF-β) receptor type 2.
CCR7, chemokine (C-C motif) receptor; CXCL8, chemokine CXC motif ligand 8; CXCR1, C-X-C chemokine receptor 1; IL-1R type I, interleukin 1 receptor
type I; ROI, reactive oxygen intermediates; TLR2, Toll-like receptor 2.
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