Biomedical Engineering Reference
In-Depth Information
R
O-CH
2
O
O-R
O
O
O
C
O
O
O
O
O-R
O-CH-(CH
2
)
4
n
n
n
POE III
POE II
POE I
(H)
O
O
O
O
O
O
CH
3
O
O
O
O
O
O-R
CH
C-O
O
R'
n
n
POE IV
Scheme 4.1
The four families of poly(ortho esters).
EtO
OEt
O
O-R
O
+
HO-R-OH
O
n
POE I
OEt
O-CH
2
R
CH
2
-CH- R-OH
+
'RC
OEt
C
OH OH
O
O-CH -(CH
2
)
4
OEt
n
POE III
Scheme 4.2
Synthesis of POE I and POE III.
O
O
O-R
H
2
O
O
+
HO-R-OH
O
n
HO-C H
2
CH
2
CH
2
COOH
Scheme 4.3
Hydrolysis of POE I.
Phase III clinical trial for the prevention of chemotherapy-induced immediate and
delayed nausea and vomiting using the delivery of granisetron. It has also com-
pleted a Phase II clinical trial to treat postoperative pain using the delivery of
mepivacaine. The developments of various proprietary products using POE II are
also ongoing.
