Biomedical Engineering Reference
In-Depth Information
technique [87]. Biochemical assays were used to quantify their recognition of lectin
proteins. Such nanoparticles are designed to be specifi cally recognized by mannose
receptors, which are highly expressed in cells of the immune system. Future
applications as vaccine delivery agents are anticipated. Thiol- capped polylactides
were used to coat photoluminescent quantum dots, which are designed as drug
delivery nanovehicles with both diagnostic imaging properties and controlled drug
release properties [88]. Another route to nanoscale particles is via micelle forma-
tion of amphiphilic block copolymers [89] . Polyethylene glycol - block - lactides were
shown to form polymeric micelles, into which paclitaxel as a model drug was
encapsulated. Biodistribution and drug release behaviors were studied.
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