Biomedical Engineering Reference
In-Depth Information
TBSO
TBSO
HO
TBSO
NO
O
O
PNP.
chloroformate
O
HN
TBSCI
NO
O
ON
O
O
NO
2
OH
OH
7
8
9
10
TBSO
TBSO
HO
TBSO
HO
HO
O
O
Amberlyst
1. TFA
2. linker I
OMe
O
N
O
N
O
N
N
O
O
O
O
N
O
ON
11
12
HO
HO
OMe
O
HO
O
O
2
N
O
O
PNP-
chloroformate
O
O
OMe
O
N
NO
O
DOX-NH
2
O
N
O
14
O
ON
O
OMe
O
OO
13
O
2
N
O
Scheme 10.3
Synthesis of the prodrug of DOX with a trigger which can be activated with catalytic antibody 38C2 [29].
