Biomedical Engineering Reference
In-Depth Information
polymer (i.e., the ratio between l - and d-amino acid units) [87]. Some of these
polymers have been studied as matrices in the form of microspheres for drug
delivery systems [88]. Similar PEAs have also been prepared by using an
unsaturated dicarboxylic acid or an oligomer derived from an
α
- amino acid and
oligoethylen glycol [89] (Scheme 6.5 d).
•
Carbohydrate derivatives. Carbohydrates like arabinose, xylose, and tartaric
acid [90] have been reacted with amino alcohols to render new PEAs whose
degradation properties were investigated [90] (Scheme 6.5e). The same pro-
cedure has been extended to succinic and glutaric acid derivatives [91, 92].
Polymers can be directional or adirectional depending on the synthesis
procedure. The hydrolytic degradation rate has proved to be strongly infl u-
enced by chain microstructure since formation of amide rings can accelerate
the process.
Acknowledgments
The authors want to indicate the fi nancial support given by CICYT and FEDER
(grant MAT 2006 - 02406).
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