Biomedical Engineering Reference
In-Depth Information
O
CH
3
O
CH
3
(C H
2
)
10
-O
O-
CH C-O-CH C-O-(CH
2
)
10
-O
O
O
O
O
O
O
O
O
O
n
H
2
O
CH
3
O
CH
3
O
(C H
2
)
10
-O
O
O
O
O-CH C-OH
HO
-CH C-O-(CH
2
)
10
-O
O
O
O
O
O
O
H
2
O
H
2
O
O
CH
3
O
O
(C H
2
)
10
-O
O
O
O-C-CH
2
CH
3
HO-CH C-OH
CH
3
CH
2
-C-O
O
OH
O
O
HO
HO-(CH
2
)
10
-OH
O
HO
HO
OH
OH
CH
3
-CH
2
-C-OH
Scheme 4.10
Details of polymer hydrolysis. For simplicity, the latent acid has been depicted
as a dimer of lactic acid.
100
100
90
90
80
80
70
70
60
60
50
50
40
40
30
30
20
20
10
10
0
0
0 0 0 0 0 0 0 0 0 0
Time (days)
Figure 4.9
The relationship between lactic
acid release (J) and weight loss (B) for a
poly(ortho ester) prepared from 3,9
diethylidene - 2,4,8,10 - tetraoxaspiro [5.5]
undecane, and a 100/70/30 mixture of
1,10 - decanediol and 1,10 - decanediol lactide;
0.13 M, pH 7.4 sodium phosphate buffer at
37 ° C. Reprinted from [21] , p. 304, with
permission from American Chemical Society.
