Biomedical Engineering Reference
In-Depth Information
TABLE 5.5
Advantages and Disadvantages of Different Reactor Types
Reactor Type
Advantages
Disadvantages
Raceway
Relatively economical
Low energy input
Easy to clean and maintain
No O 2  build-up
Large production capacity
Little control of culture conditions
Poor mixing
Light limitation
Readily contaminated
Limited growing period
Poor productivity
Large land area required
Limited CO 2  mass transfer with large
CO 2  losses to atmosphere if pond
sparged
Temperature determined by climate
Vertical column PBR
Excellent mixing
High mass transfer rates
Low shear stress
Easy to clean and sterilize
Reduced photo-inhibition
Low cost
Low land area requirement
Low angle to incident sunlight
Size limited by area:volume ratio
Large mixing energy due to gas
compression
Tubular PBR
Large illuminated surface area
Good biomass productivity
Relatively cheap construction
materials
Gradients of pH, O 2 , and CO 2
along tubes
Wall growth: fouling in tubes difficult to
clean
Large land area required
Significant water losses if evaporative
cooling is used
Possible hydrodynamic stress
Flat-plate PBR
Large illuminated surface area
Short light path
Good biomass productivity
Easier to clean
Lower O 2  build-up
Scale-up requires many modules -
material intensive
Temperature control critical in thin
reactors
Source: From Borowitzka (1999); Pulz (2001); Chisti (2007); Ugwu et  al. (2008); Brennan and
Owende (2010); Mata et al. (2010).
(Lee, 2001). To expand the product range, there is significant interest in the design
of closed reactors, particularly in the production of high-value, low-volume prod-
ucts requiring a high degree of sterility. The essence of the debate is presented in
Table 5.6 through a comparison of the key parameters of open and closed reactors.
Despite their higher cost and technical complexity, closed systems promise great
improvements in enhancing control over process parameters. The challenge appears to
 
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