Cell-Based Chips for Biotechnology - Introduction to BioMEMS - page 251

Sheath

Sample

a b

Chevrons

Sheath

Core

c

Q C

Sheath Sheath

d

Q S :Q C :Q S =
14.5:1:14.5

Q S Q S

A

A - Before chevrons

e

A

390 µm

a

A

B - After chevrons

130 µm

b

B

c

FIGURE 5.5 3-D.hydrodynamic.focusing.using.chevron.grooves..(From.Peter.B..Howell.Jr.,.Joel.P..
Golden, Lisa.R..Hilliard,.Jeffrey.S..Erickson,.David.R..Mott,.and.Frances.S..Ligler,.“Two.simple.and.
rugged.designs.for.creating.microluidic.sheath.low,”. Lab Chip .8,.1097-1103,.2008;.and.Joel.P..
Golden,. Jason. S.. Kim,. Jeffrey. S.. Erickson,. Lisa. R.. Hilliard,. Peter. B.. Howell,. George. P.. Anderson,.
Mansoor.Nasir,.and.Frances.S..Ligler,.“Multi-wavelength.microlow.cytometer.using.groove-generated.
sheath.low,”. Lab Chip .9,.1942-1950,.2009..Reproduced.with.permission.from.The.Royal.Society.
of.Chemistry.)

B

1

a 1 b

A

2

2

D

3

C

3

200 µm

4

4

FIGURE 5.6 Single-layer.microluidic.device.producing.3-D.focused.low..(From.Xiaole.Mao,.Sz-Chin.
Steven. Lin,. Cheng. Dong,. and. Tony. Jun. Huang,. “Single-layer. planar. on-chip. low. cytometer. using.
microluidic.drifting.based.three-dimensional.(3D).hydrodynamic.focusing,”. Lab Chip .9,.1583-1589,.
2009..Reproduced.with.permission.from.The.Royal.Society.of.Chemistry.)