Biomedical Engineering Reference
In-Depth Information
cellulite grading following treatment, with both LAL and
mechanical disruption improving one point on a 4-point
scale. Patient-scored improvement did not differ between
treatment sides, but physician scoring indicated increased
improvement on the LAL-treated side. Future, large-scale
studies are necessary to determine whether LAL is a viable
treatment option for cellulite.
In situ temperature feedback has been reported using the
1064/1319-nm multiplex laser liposuction device (44).
Employing a target tissue temperature of 45-48°C, the study
of 12 subjects treated for submental lipodystrophy demon-
strated no dermal injury, thermal burns, or postoperative
complications.
Finally, the 1444-nm wavelength has been used as an alter-
native means of facial contouring. In a study of 478 patients
who underwent “laser-assisted facial contouring,” Holcomb
et al. (56) treated mid and lower face localized adiposity with
a wide breadth of outcomes from minimal improvement to
marked changes in facial contour. Treatment complications
were 13%, but over 60% of complications were undercorrec-
tion of the perceived defect.
8. Blugerman GB. Laser lipolysis for the treatment of localized adiposity
and “cellulite”. Abstracts of World Congress on Liposuction Surgery.
Dearborn, Michigan, 2000.
9. Schavelzon DS, Blugerman G, Goldman A, et al. Laser lipolysis. Abstracts
of the 10th International Symposium on Cosmetic Laser Surgery. Las
Vegas, Nevada, 2001.
10. Goldman AG, Schavelzon D, Blugerman G. Liposuction using
neodymium:yttrium-aluminium-garnet laser. Abstr Plast Reconstr Surg
2003; 111: 2497.
11. Goldman A, Schavelzon DE, Blugerman GS. Laserlipolysis: Liposuction
using Nd:YAG laser. Rev Soc Bras Cir Plast 2002; 17: 17-26.
12. Badin AZD, Moraes LM, Gondek L, Chiaratti MG, Canta L. Laser lipolysis:
fl accidity under control. Aesth Plast Surg 2002; 26: 335-9.
13. Uebelhoer NS, Ross EV. Introduction: update on lasers. Semin Cutan Med
Surg 2008; 27: 221-6.
14. Goldman A, Gotkin RH. Laser-assisted liposuction. Clin Plast Surg 2009;
36: 241-53.
15. Katz B, McBean J. The new laser liposuction for men. Dermatol Ther
2007; 20: 448-51.
16. Katz B, McBean J. Laser-assisted lipolysis: a report on complications.
J Cosmet Laser Ther 2008; 10: 231-3.
17. Goldman A. Submental Nd:YAG laser-assisted liposuction. Lasers Surg
Med 2006; 38: 181-4.
18. Kim KH, Geronemus RG. Laser lipolysis using a novel 1064 nm Nd:YAG
laser. Dermatol Surg 2006; 32: 241-8.
19. Goldman A, Wollina U, de Mundstock EC. Evaluation of tissue tightening
by the subdermal Nd:YAG laser-assisted liposuction versus liposuction
alone. J Cutan Aesthet Surg 2011; 4: 122-8.
20. Stebbins WG, Hanke CW, Petersen J. Novel method of minimally invasive
removal of large lipoma after laser lipolysis with 980 nm diode laser.
Dermatol Ther 2011; 24: 125-30.
21. Reynaud JP, Skibinski M, Wassmer B, Rochon P, Mordon S. Lipolysis
using a 980-nm diode laser: a retrospective analysis of 534 procedures.
Aesth Plast Surg 2009; 33: 28-36.
22. Parlette EC, Kaminer ME. Laser-assisted liposuction: here's the skinny.
Semin Cutan Med Surg 2008; 27: 259-63.
23. Mordon SR, Wassmer B, Reynaud JP, Zemmouri J. Mathematical
modeling of laser lipolysis. Biomed Eng Online 2008; 7: 10-24.
24. Sun Y, Wu SF, Yan S, et al. Laser lipolysis used to treat localized adiposis: a
preliminary report on experience with Asian patients. Aesth Plast Surg
2009; 33: 701-5.
25. Badin AZED, Gondek LBE, Garcia MJ, et al. Analysis of laser lipolysis
effects on human tissue samples obtained from liposuction. Aesth Plast
Surg 2005; 29: 281-6.
26. DiBernardo BE, Reyes J, Chen B. Evaluation of tissue thermal effects from
1064/1320-nm laser-assisted lipolysis and its clinical implications.
J Cosmet Laser Ther 2009; 11: 62-9.
27. McBean JC, Katz B. A pilot study of the effi cacy of a 1064 nm and 1320
nm sequentially fi ring Nd:YAG laser device for lipolysis and skin
tightening. Lasers Surg Med 2009; 41: 779-84.
28. Woodhall KE, Saluja R, Khoury J, Goldman MP. A comparison of three
separate clinical studies evaluating the safety and effi cacy of laser-assisted
lipolysis using 1,064, 1,320 nm, and a combined 1,064/1,320 nm multiplex
device. Lasers Surg Med 2009; 41: 774-8.
29. Wassmer B, Zemmouri J, Rochon P, Mordon S. Comparative study of
wavelengths for laser lipolysis. Photomed Laser Surg 2010; 28: 185-8.
30. Goldman A, Gotkin RH, Sarnoff DS, Prati C, Rossato F. Cellulite: a new
treatement approach combining subdermal Nd:YAG laser lipolysis and
autologous fat transplantation. Aesth Surg J 2008; 28: 656-62.
31. Khoury JG, Saluja R, Keel D, Detwiler S, Goldman MP. Histologic
evaluation of interstitial lipolysis comparing a 1064, 1320, and 2100 nm
laser in an ex vivo model. Lasers Surg Med 2008; 40: 402-6.
32. Mordon S, Blanchemaison Ph. Letter to the editor: “Histologic evaluation
of interstitial lipolysis comparing a 1064, 1320 and 2100 nm laser in an ex
vivo model”. Lasers Surg Med 2008; 40: 519.
33. Reszko AE, Magro CM, Diktaban T, Sadick N. Histological comparison of
1064 nm Nd:YAG and 1320 nm Nd:YAG laser lipolysis using an ex vivo
model. J Drugs Dermatol 2009; 8: 377-82.
34. Mordon S, Wassmer B, Rochon P, et al. Serum lipid changes following
laser lipolysis. J Cosmet Laser Ther 2009; 11: 74-7.
35. Ichikawa K, Miyasaka M, Tanaka R, et al. Histologic evaluation of the
pulsed Nd:YAG laser for laser lipolysis. Lasers Surg Med 2005; 36: 43-6.
conclusion
LAL development has occurred rapidly over the last decade
with the advancement of device platforms, usable wavelengths,
surgical techniques, and new indications. Six wavelengths have
been FDA approved for use with LAL: 924/975, 980, 1064,
1320, and 1444 nm. To date, the 1064-nm wavelength has the
largest body of cumulative clinical studies regarding its use
in LAL (57).
LAL is a safe technique in experienced hands and proper
monitoring. Although LAL theoretically may have distinct
advantages to traditional liposuction, well-constructed clinical
studies are needed to defi nitively demonstrate possible advan-
tages, as some experts still debate the utility of this technology
(58). More precise laser and light devices, improved technol-
ogy, and a reduced side effect profi le will be introduced into
the market. Future studies may better characterize treatment
parameters and the optimal technology for use in LAL.
acknowledgments
This chapter derives material from the chapter on laser lipoly-
sis by Melanie Palm and Mitchel Goldman in
Seminars in
Cutaneous Medicine and Surgery
2009; 28(4): 212-19.
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