Photodynamic therapy - Lasers and Energy Devices for the Skin - page 262

Table 10.6 Published Clinical Studies on ALA- and MAL-PDT for Acne Vulgaris ( Continued )

Photosensitizer/
Duration/
Study Design

Location/
Pretreatment

Number of
Sessions

Light Source
(Emission λ , nm) Reference # Patients Response Follow-up (wk)

Akaraphanth (216)
(2007)

10% ALA in acne
spots, 1 hr/
split-face blue
light + ALA vs.
blue light alone

Face/not mentioned 4 (1 wk apart) 20 Blue LED (409-410

nm), 48 J/cm 2 , 40
mW/cm 2

Blue + ALA: 71.1%
reduction of
infl ammatory
lesions vs. blue
light alone: 56.7%;
(no statistical
difference)

16

Yeung (222) (2007) 16.8% MAL,

30 min/split-face
MAL + IPL, IPL
alone or control
(ratio of 1:2:1); all
patients used
0.1% adapalene
during the study

Face/soap followed
by alcohol scrub

4 (3 wk apart) 23 (11 with

MAL-PDT)

IPL (530-750 nm),
7-9 J/cm 2

MAL-PDT: 65%
reduction of
infl ammatory
lesions vs. IPL:
23% vs. control:
88% (no statistical
difference)

3 mo after last
treatment

Hörfelt (230) (2007) 20% ALA, 3 hr/

split-area
with different
light doses

Face and back/not
mentioned

1 14 (9 Cheek,

5 Back)

Noncoherent red
(600-730 nm),
50 mW/cm 2 , 50 or
30 J/cm 2 (cheek);
50 or 70 J/cm 2
(back)

No difference in
clinical results
between the
2 doses for face
and back,
8/9 patients
with face acne
had some
improvement

10 (cheek) and
20 wk (back)

Oh (222) (2009) 20% ALA/split-face

30 min or 3 hr
incubation
ALA-IPL vs. IPL
only

Face/soap and 70%
alcohol

3 (4 wk apart) 20 IPL cutoff fi lter

590 nm,
12-15 J/cm 2

Clearance of 89.5%
(3 hr), 83% (30
min), and 74%
(IPL only). Long
incubation group
and IPL-only
group were
statistically
different

12 wk after last
treatment

Yin (230) (2010) 5%, 10%, 15%, and

20% ALA, 1.5 hr
occlusion/
split-face
ALA-PDT vs.
placebo-
red light cm 2

Face/70% isopropyl
alcohol

4 (10 days apart) 180 Red light (633 ±

3 nm), 126 J/cm 2

Statistically
signifi cantly more
patient treated
with 20% ALA
achieved complete
clearance, no
statistical
difference between
15 and 20% at
12 wk or more.

24 wk

Abbreviations : ALA, aminolevulinic acid; IPL, intense pulsed light; LED, light-emitting diode; LPDL, long-pulsed dye laser; MAL, methyl aminolevulinic acid; PDT, photodynamic therapy.