Biomedical Engineering Reference
In-Depth Information
Table 10.6
Published Clinical Studies on ALA- and MAL-PDT for Acne Vulgaris
Photosensitizer/
Duration/
Study Design
Location/
Pretreatment
Number of
Sessions
Light Source
(Emission
Reference
# Patients
λ
, nm)
Response
Follow-up (wk)
Hongcharu (212)
(2000)
20% ALA, 3 hr
occlusion/3 test
sites and 1 control
site on back per
patient (ALA only,
ALA-PDT, red
light only,
control); 2
randomized
groups: 1 vs.
4 sessions
(1 wk apart)
Back/70% isopropyl
alcohol
1 vs. 4
22
Broad-spectrum
(550-700 nm,
150 J/cm
2
)
Only ALA-PDT
showed signifi cant
reduction in
infl ammatory
lesions, 4 sessions
better than 1
20
Itoh (213) (2001)
20% ALA,
4 hr occlusion
Face/not mentioned
1
13
Broad-spectrum
(600-700 nm,
17 mW/cm
2
,
13 J/cm
2
)
100% with some
improvement,
new lesions after
3-6 mo
24
Goldman (215)
(2003)
20% ALA, 15 min/
blue light only vs.
ALA-PDT
Face/2% salicylic
acid cleanser
2 Sessions of blue
light alone weekly,
2 sessions of
ALA-PDT at 2 wk-
intervals
22 (12 blue light vs.
10 ALA-PDT)
Blue light (417 nm)
68% Decrease of
papules in the
ALA-PDT vs. 40%
decrease in the
blue light alone
2 wk after last
treatment
Pollock (210) (2004)
20% ALA, 3 hr
occlusion/3 test
sites and 1 control
site on back per
patient (ALA only,
ALA-PDT, red
light only, control)
Back/not men-
tioned
3, 1 wk apart
10
Diode laser (635
nm, 25 mW cm
2
,
15 J cm
2
)
Signifi cant
reduction of mean
acne lesions count
(69%) in the
ALA-PDT site
only
3 wk after last
treatment
Gold (217) (2004)
20% ALA, 1 hr
Face/Cetaphil
cleanser
4 (1 wk apart)
15
IPL (430-1100 nm,
3-9 J/cm
2
)
3 Patients did not
respond, 12
patients had
71.8% reduction
in acne lesions
12
Taub (214) (2004)
20% ALA, 15-30
min
Face, back and
chest/acetone
scrub and alcohol
scrub
2-4 (4-8 wk apart)
18
Blue light (417 nm)
or IPL(400-980
nm, 18-25 J/cm
2
+
radiofrequency)
5 Patients did not
improve, 11 had at
least 50%
improvement
Average follow-up
time of 4 mo
Hong (226) (2005)
20% ALA, 4 hr
under occlusion/
split-face
ALA-PDT vs.
controls
Face/not mentioned
1
8
Halogen lamp red
light (630 ± 63
nm, 30 mW/cm
2
,
18 J/cm
2
)
41.9% (treated) vs.
15.4% (control)
reduction of
infl amed lesions at
6 mo
6 mo
