Biomedical Engineering Reference
In-Depth Information
Table 10.5
Published Clinical Studies on ALA- and MAL-PDT for Photorejuvenation (
Continued
)
MAL-PDT Study
Design
Location of
Photodamage
Incubation Period
(hr)
Light Source
(Emission
Reference
# Patients
λ
, nm)
Response
Follow-up (mo)
Zane (173) (2007)
2 Sessions, 1-mo
interval
Facial AK and
severe
photodamage
3, Occluded (2-3
tubes for each
session)
20 (137 AKs)
Red LED (634 ±
3 nm, 37 J/cm
2
)
88.3% CR of AKs,
improvement of
hyperpigmented
spots, sallowness,
skin texture, and
fi ne lines,
erythema,
telangiectasia,
sebaceous gland
hypertrophy, and
deep wrinkles,
showed no change
2 mo after last
treatment
Ruiz-Rodriguez (185)
(2007)
2 Sessions, 3 wk
apart
Perioral, pretreat-
ment with
fractional
resurfacing (1550
nm), a half
followed by
MAL-PDT
3, Occluded
4
Red LED (634 ±
3 nm, 37 J/cm
2
)
Increased improve-
ment in superfi cial
wrinkles in 3 out
of 4 patients on
the combined
treatment side
12 wk after last
treatment
Issa (174) (2010)
2 sessions, 1-mo
interval
Facial AK and
photodamage
(Glogau classifi ca-
tion types II and
III)
2, Occluded (1/2
tube for each
session)
14
Red LED (634 ±
3 nm, 37 J/cm
2
)
89.1% CR of AKs
after 6 mo; 10/14
patients: improve-
ment of skin
texture, wrinkles
and fi rmness and
pigmentation;
increase in
collagen fi bers
density and
decrease in
elastotic material
assessed through
morphometric
exam 6 mo after
treatment
6
Abbreviations
: AKs, actinic keratoses; ALA, aminolevulinic acid; CR, clearance rate; DMSO, dimethyl sulfoxide; IPL, intense pulsed light; LED, light-emitting diode; MAL, methyl aminolevulinic acid; nBCC, nodular basal cell carcinoma;
PDL, pulsed dye laser; PDT, photodynamic therapy; PIH, postinfl ammatory hyperpigmentation.
