Photodynamic therapy - Lasers and Energy Devices for the Skin - page 239

Soler (267) (2000) ALA-PDT 15 min

of pretreatment
with 99% DMSO
before topical
20% ALA with
DMSO (2%)
and ethylene-
diaminetetraacetic
acid (2%)

Face, scalp, trunk,
and extremities

3 occluded 245 (83) Broadband lamp

with continuous
spectrum
(570-740 nm) or
a red-light laser
(630 nm)

Red light : 86% CR
vs. Broadband
lamp : 82% CR

6

Wang (141) (2001) 20% cream 1× ALA

PDT × Cryother-
apy 2× freeze-
thaw cryotherapy,
repeat at 12 wk, if
required

Head and neck,
trunk, and limbs

6 occluded 39 sBCC (22 treated

with ALA-PDT)
49 nodular BCC
(25 treated with
ALA-PDT)

Frequency doubled
Nd:YAG laser
pumping a dye
laser (635 nm,
60 J/cm 2 , 80 ±
20 mW cm 2 )

12 mo histologically
recurrences: 38%
for ALA-PDT vs.
7% for cryother-
apy; Excellent or
good cosmetic
outcome (sBCC +
nBCC) in 93%
treated with
ALA-PDT vs. 54%
with cryotherapy

12

MAL-PDT Study
Design

Incubation
Period (hr)

# Lesions Treated
(# Patients)

Light Source
(wavelength in nm) Reference Location Response Rate Follow-up (mo)

Soler (162) (2001) 1× MAL-PDT

(lesion prepara-
tion)

Face, scalp, trunk,
and extremities

Mean 4 occluded 131 sBCC Broadband

halogen light
(570-670 nm)
mean light dose of
50-200 J/cm 2 ,
light intensity of
100-180 mW/cm 2

91% CR after
3 mo, 9% relapse
at 35 mo

24-48

Horn (143) (2003) MAL-PDT “diffi cult

to treat” BCC
(European trial)
2× MAL-PDT
retreated after
3 mo if necessary
(lesion
preparation)

Face, scalp, neck,
trunk, and
extremities

3, Occluded 49 sBCC Red light

(570-670 nm),
dose of
75 J/cm 2 , light
intensity of
50-200 mW/cm 2

85% CR after
3 mo (histological
control);22%
recurrence at
24 mo

24

( Continued )