Biomedical Engineering Reference
In-Depth Information
Table 10.1
Published Clinical Studies on ALA- and MAL-PDT for AKs (
Continued
)
Light Source
(Wavelength
in nm)
MAL-PDT Study
Design
Incubation
Period (hr)
# Lesions Treated
(# Patients)
Reference
Location
Response Rate
Follow-up (mo)
Tarstedt (97) (2005)
Comparison:
1× MAL-PDT
repeated if
necessary at 3 mo
vs. 2× MAL-PDT
Face and scalp
3, Occluded
400 AKs in
211 patients
Red LED light
source (634 ±
3 nm, 37 J/cm
2
,
50 mW cm
2
)
1× MAL-PDT
repeated if
necessary-92%
(81% after fi rst
treatment) vs.
2× MAL-PDT-87%
3 After last
treatment
Morton (93) (2006)
1× MAL-PDT vs.
cryotherapy (2
freeze cycle),
repeat at 12 wk, if
required
Face and scalp
3, Occluded
1505 AK in
119 patients
Red LED light
source (634 ±
3 nm, 37 J/cm
2
,
50 mW/cm
2
)
MAL-PDT-89%
(84% after
1 treatment) vs.
cryotherapy 86%
(75% after
1 treatment)
3 After last
treatment
Perrett (99) (2007)
MAL-PDT in
transplant
patients,
2× MAL-PDT vs.
topical 5-FU twice
daily for 3 wk
Head, trunk, and
extremities
3, Occluded
18 lesional areas
were treated
(10 Carcinoma
in situ and 8 AK)
in 8 OTR patients
Noncoherent red
light source (633
± 15 nm light dose
of 75 J cm, light
intensity of
80 mW/cm
2
8 of 9 lesional areas
(89%) cleared with
MAL-PDT vs. 1 of
9 lesional areas
(11%) cleared with
5-FU
6
Kauffman (94) (2008)
1× MAL-PDT vs.
2× freeze-thaw
cryotherapy,
repeat at 12 wk, if
required
Extremities (98%),
trunk, and neck
3, Occluded
1343 AK in 121
patients (691
treated with
MAL-PDT)
Red LED light
source (634 ±
3 nm, 37 J/cm
2
,
50 mW/cm
2
)
MAL-PDT-78% vs.
cryotherapy-88%
6
Palm (106) (2011)
MAL-PDT blue
light vs. red light
Face, scalp, chest,
and back
1
(18)
PDL (7 mm,
10-12 J/cm
2
,
40 ms) +/− IPL, +
blue light (
407 nm, 10 J/cm
2
,
16 min, 40 s) vs.
Red LED light
(630 nm, 37 J/cm
2
,
8 min, 49 s)
No difference in
improvement in
AKs, wrinkles,
pigmentation, or
erythema between
red and blue light
1
Abbreviations
: AKs, actinic keratoses; ALA, aminolevulinic acid; BCC, basal cell carcinoma; MAL, methyl aminolevulinic acid; PDT, photodynamic therapy; SCC, squamous cell carcinoma; RR, relapse rate; CR, clearance rate;
IPL, intense pulsed light; OTR, organ transplant recipients; 5-FU, 5-fl uorouracil; LED, light-emitting diode; PDL, pulsed dye laser; mo, month.
