Biomedical Engineering Reference
In-Depth Information
Table 10.1
Published Clinical Studies on ALA- and MAL-PDT for AKs (
Continued
)
Light Source
(Wavelength
in nm)
Incubation
Period (hr)
# Lesions Treated
(# Patients)
Reference
ALA Preparation
Location of AKs
Response Rate
Follow-up (mo)
Varma (86) (2001)
20% Ointment
Not specifi ed
4, Occluded
127 (88 Patients
with mixed
diagnoses)
Waldmann red
lamp (580-740)
77% CR after 1st
session, 99% after
2nd session, RR
of 28%
6
Ruiz-Rodriguez (166)
(2002)
20% Emulsion
Face, scalp
4, Occluded
38
IPL (590-1200)
76% CR 1 session;
91% CR 2 sessions
3
Alexiades-Armenakas
(73) (2003)
20% Solution
Head, extremities,
trunk
3 with Occlusion;
14-18 without
occlusion
3622 (36)
PDL (595)
90-100% CR
8
Clark (46) (2003)
20% Ointment
Not specifi ed
4
23
Metal halide
(590-730);
halogen lamp
(570-680), diode
laser (630)
91% CR
11
Goldman (72) (2003)
20% Solution
Face, long-
incubation PDT
15-20
(32)
Blue light (417)
94% CR of AKs;
improved skin
texture,
pigmentation
3-6
Smith (81) (2003)
20% Solution,
2 sessions
Face, scalp
1
(35)
Blue light (417) or
PDL (595)
80% CR for blue
light; 60% CR
for PDL
1
Dragieva (101) (2004)
20% Emulsion;
transplant patients
Face, scalp
5, Occluded
32 (20)
Red light (580-740)
94% CR at 4 wk;
72% at 48 wk
12
Piacquadio (78)
(2004)
20% Solution,
1-2 sessions
Face, scalp
14-18
1402 (243)
Blue (417)
91% CR 1st session;
83% CR 2nd
session
3
Touma (22) (2004)
20% Solution
Face
1-3
(17)
Blue lamp (417)
87-94% CR
5
Gilbert (107) (2005)
20% Solution,
5-FU daily ×
5 days pre-PDT
Face
0.5-0.75
(15)
IPL (560-1200)
90% CR with
combination
therapy
12
Kim (87) (2005)
20% Emulsion
Face
4, Occluded
12 (7)
IPL (555-950)
50%
3
Tschen (67) (2006)
20% Solution,
(1-2 treatment
sessions)
Face, scalp
14-18
968 (110)
Blue (417)
72-76% CR 1st
session; 86% 2nd
session
12
Nakano (83) (2009)
20% Cream
(3 treatment
sessions)
Face
4, Occluded
(30)
Excimer dye laser
(630 nm)
100% CR in lesions
<10 mm; 70% CR
in lesions >10 mm
diameter
12
