Biomedical Engineering Reference
In-Depth Information
Table 10.1
Published Clinical Studies on ALA- and MAL-PDT for AKs
Light Source
(Wavelength
in nm)
Incubation
Period (hr)
# Lesions Treated
(# Patients)
Reference
ALA Preparation
Location of AKs
Response Rate
Follow-up (mo)
Kennedy (74) (1990)
20% Emulsion
Not specifi ed
3-6
10
Tungsten (>600)
90% CR
18
Wolf (21) (1993)
20% Emulsion
Face and scalp
4-8
9
Tungsten, unfi ltered
100% CR
3-12
Calzavara-Pinton (17)
(1995)
20% Cream
Face
6-8
50 (from pool of
85 patients with
AKs, BCCs, SCCs,
Bowen's disease)
Argon dye laser
(630)
100% CR
24-36
Morton (263) (1995)
20% Emulsion
Face and scalp
4
4
Xenon (630)
100% CR
12
Fijan (264) (1995)
20% Emulsion
Not specifi ed
20, Occluded
43 (9)
Halogen (570-690)
81% CR
3-20
Szeimies (265) (1996)
10% Emulsion
Head, hands, arms
6, Occluded
36 (10)
Waldmann red
lamp (580-740)
71% CR head
1
Fink-Puches (89)
(1997)
20% Emulsion
Head, neck,
forearms, dorsal
hands
4, Occluded
251 (28)
Halogen slide
projector
(300-800) with
cutoff fi lters at
515, 530, 570, 610
71% CR
36
Fritsch (80) (1997)
10% Ointment
Face and scalp
6, Occluded
(6)
Green lamp
(543-548) vs. red
Waldmann lamp
(570-750)
100% CR for both
green and red light
15
Jeffes et al. (1997)
0-30% Emulsion
Face, scalp, trunk,
extremities
3, Occluded
240 (40)
Argon dye laser
(630)
91% CR face and
scalp; 45% CR
trunk and
extremities
2
Karrer et al. (1999)
20% Emulsion
Scalp, face
6, Occluded
200 (24)
Red light lamp
(580-740) or
PDL (585)
84% CR (red light)
79% CR (PDL)
1
Kurwa et al. (1999)
20% Emulsion
Hands
4, Occluded
(14)
Metal halide lamp
(580-740)
73% Lesion area
reduction;
comparable to
5-FU
6
Itoh (85) (2000)
20% Emulsion, 2 or
more sessions
Face, neck,
extremities
4, Occluded
53 (10)
Red lamp (peak
630, range
600-700), excimer
dye laser (630)
82% CR face and
neck; 56% CR
extremities
12
Dijkstra (75) (2001)
20% Gel, 2 sessions
Unspecifi ed
8, Occluded
4
Violet lamp
(400-450)
50% CR
3-12
Jeffes (68) (2001)
20% Solution
Face, scalp
14-18
70 (36)
Blue light (417)
85% CR
4
Markam (48) (2001)
% Concentration
unspecifi ed, cream
Scalp
4, Occluded
(4)
Red light (580-740)
75% CR
6
(
Continued
)
