Biotransformation (Metabolism) of Pesticides - Pesticide Biotransformation and Disposition - page 81

Table 5.3 Human Phase I Xenobiotic-Metabolizing Enzymes Active in Pesticide Metabolism
Phase I isoform

Substrate Reference

Alcohol
dehydrogenase-a

Permethrin metabolite:
phenoxybenzyl alcohol

Choi et al. (2002)

Alcohol
dehydrogenase β-I

Permethrin metabolite:
phenoxybenzyl alcohol

Choi et al. (2002)

Alcohol
dehydrogenase β-II

Permethrin metabolite:
phenoxybenzyl alcohol

Choi et al. (2002)

Alcohol
dehydrogenase-γ

Permethrin metabolite:
phenoxybenzyl alcohol

Choi et al. (2002)

Aldehyde
dehydrogenase
Aldehyde oxidase

Neonicotinoids Dick et al. (2005); Honda et al. (2006)

ALDH3A1 Permethrin metabolite:

phenoxybenzyl aldehyde

Choi et al. (2002)

CYP1A1 Insecticides

Carbaryl

Tang et al. (2002)

Carbofuran Usmani et al. (2004a)

Sulprofos Usmani et al. (2004b)

Herbicides
Diuron

Abass et al. (2007a)

Ametryne Lang et al. (1996, 1997)

Atrazine Joo et al. (2010); Lang et al. (1996, 1997)

Terbuthylazine Lang et al. (1996, 1997)

Terbutryne Lang et al. (1996, 1997)

Insect repellent: DEET Usmani et al. (2002)

CYP1A2 Anthelminthic:

thiobendazole

Coulet, 1998

Insecticides
Azinphos-methyl Buratti et al. (2002, 2003)

Carbaryl Tang et al. (2002)

Carbofuran Usmani et al. (2004a)

Chlorpyrifos Buratti et al. (2002, 2003) ; Foxenberg et al.

(2007); Tang et al. (2001); Mutch and Williams
(2006); Sams et al. (2004)

Diazinon Buratti et al. (2002, 2003) ; Mutch and Williams

(2006)

Disulfoton Usmani et al. (2004b)

Fenthion Leoni et al. (2008)

Imidacloprid Schultz-Jander and Casida (2002)

Malathion Buratti et al. (2005)

Methiocarb Usmani et al. (2004b)

Parathion Buratti et al. (2003); Butler and Murray (1997);

Foxenberg et al. (2007); Mutch et al. (1999,
2003, 2006) ; Sams et al. (2000)

Phorate Hodgson et al. (1998); Usmani et al. (2004b)

Sulprofos Usmani et al. (2004b)