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Figure 4.1
(Continued)
cooxidation during prostaglandin synthesis. Emphasis has also been placed on the phase
II conjugation reactions as they apply to pesticide metabolism.
By definition, microsomal enzymes are those found in the high-speed particulate
microsomal fraction of tissues following homogenization and differential centrifuga-
tion. The terms microsomal fraction and microsomes refer to a biochemical prepa-
ration and do not correspond to any particular cell structure. However, the major
component consists of membranous vesicles derived from the endoplasmic reticulum
and its constituent ribosomes. The microsomal fraction consists primarily of rough
(with ribosomes) and smooth (without ribosomes) vesicles that correspond to rough
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