Biotransformation of Individual Pesticides: Some Examples - Pesticide Biotransformation and Disposition - page 203

Cl

Cl

OH

N N

N N OH

H N

N
H

H N H

HIATZ (C5) HLM HLM HEATZ (C4)

Cl

N N

HLM CYP1A1, CYP1A2, CYP2B6, CYP2C8, CYP2C9*1
CYP2C19, CYP2E1, CYP3A4, CYP3A7

HLM CYP1A, CYP1A2,
CYP2C19, CYP3A4

H N

N
H

ATZ (C1)

Cl

Cl

N N

N

N

HN H N

NH2

N H

GSH
HL S9

Enzymatic and
non-enzymatic

A (C2) DIA (C3)

Enzymatic and
non-enzymatic

GSH
HL S9

Enzymatic and
non-enzymatic

GSH
HL S9

NH 2 HN

HN

N N O N N O

N N O

HN HN

S
O

S
O

N NH N NH

H 2 N

S
O

O O N NH

NH NH O

NH

OH OH

OH

O O O

O

NH 2 NH 2

NH 2

OH OH

OH

DEA-SG (C7) ATZ-SG (C6) DIA-SG (C8)

Figure 9.9 In vitro metabolism of triazine herbicides—atrazine in humans. Adapted from Joo et al. (2010).