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O
O
N
H
OH
OSO
3
H
OH
O
O
H
OGlu
O
O
H
OH
OH
OH
O
O
H
O
O
N
H
O
H
O
O
NH
2
OH
H
OH
O
H
O
O
O
N
H
OH
O
H
OH
OH
Figure 9.1
(Continued)
The principal metabolites produced in vitro by human liver microsomes are
5-hydroxycarbaryl, 4-hydroxycarbaryl, and carbaryl methylol. Most of the 16 recombi-
nant human CYP isoforms tested had some activity toward carbaryl, with CYP1A1 and
CYP1A2 having the greatest ability to form 5-hydroxycarbaryl, CYP3A4 and CYP1A1
to form 4-hydroxycarbaryl, and CYP2B6 to form carbaryl methylol (
Tang et al., 2002
).
Organochlorine Insecticides—DDT
Although DDT has long been banned in the United States, Europe, and elsewhere, it is
still used to some extent in public health, for example in mosquito control, elsewhere
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