Metabolic Interactions of Pesticides - Pesticide Biotransformation and Disposition - page 154

Table 7.2 (Continued)
Inducer and/or substrate Species Effect Reference

FUNGICIDES
Griseofulvin

Human Pharmacological action of warfarin decreased Cullen and Catalano (1967)

Parnon Rat In vitro metabolism increased Hoffman et al. (1968)

Azoles Rat Increase in liver weight, liver pathology, total CYPs,

CYPs 2B1 and 3A2, and associated enzyme activities

Barton et al. (2006); Sun et al. (2006,
2007) ; Martin et al. (2007)

Azoles Mouse Increase in liver weight, liver pathology, total CYPs,

CYPs 2B1 and 3A2, and associated enzyme activities

Allen et al. (2006); Ward et al.
(2006); Sun et al. (2006)

PYRAZOLE INSECTICIDE
Fipronil Human Increased CYP isoforms in hepatocytes Das et al. (2006)

PESTICIDE ADJUVANT
Toximul Mouse PPAR-dependent increases in peroxisomal acyl-CoA

oxidase, thiolase, and Cyp4a10 and 4a14

Upham et al. (2007)

INSECT REPELLENT
DEET

Human Increased CYP isoforms in hepatocytes Das et al. (2008a,b)

Adapted from Hodgson and Meyer (2009).