Metabolic Interactions of Pesticides - Pesticide Biotransformation and Disposition - page 150

Table 7.2 Induction of Microsomal Enzyme Activity Following Treatment, in Vivo, and Involving Pesticides as Either Inducers or Substrates
Inducer and/or
substrate Species Effect Reference

SYNERGISTS
Sesoxane Mouse Hexobarbital sleeping time increased Fine and Molloy (1964)

Piperonyl butoxide Mouse Hexobarbital sleeping time increased Fine and Molloy (1964)

Hexobarbital sleeping time increased up to12 h,
decreased after 24-72 h; parathion toxicity increased
after 1 h, decreased after 48 h

Kamienski and Murphy (1971)

Microsomal CYP content decreased after 2-12 h,
increased after 12-36 h

Philpot and Hodgson (1971-1972)

Induction of CYP 2B10, 1A1, and 1A2; 1A2 by an
Ah-independent mechanism

Philpot and Hodgson (1971-1972);
Lewandowski et al. (1990); Adams
et al. (1993a,b, 1995) ; Ryu et al.
(1996); Cook and Hodgson (1985,
1986)

CHLORINATED HYDROCARBON INSECTICIDES
BHC

Rat In vitro metabolism of hexobarbital increased,

hexobarbital sleeping time decreased, scillicocide
toxicity decreased; all isomers similar

Koransky et al. (1964)

Trichloro-237 Rat Hexobarbital sleeping time decreased Hart and Fouts (1963)

g-Chlordane Rat Hexobarbital sleeping time decreased Hart and Fouts (1963)

Endrin Rat Hexobarbital sleeping time decreased Hart and Fouts (1963)

DDT Rat No effect on hexobarbital sleep time Hart and Fouts (1963)

Hexobarbital sleep time decreased; hexobarbital
metabolism in vitro increased; metabolism of
aminopyrine increased; metabolism of p -nitrobenzoic
acid increased; no effect on aniline metabolism;
increased detoxication of EPN; increased
O-demethylation of p -nitroanisole.

Hart and Fouts (1963); Kinoshita
et al. (1966)

Increase in CYP2B and CYP3A Li et al. (1995)

DDT Squirrel

monkey

Increased N-demethylation of aminopyrine Cranmer et al. (1972)