Distribution and Pharmacokinetics Models - Pesticide Biotransformation and Disposition - page 127

Compartment
1

Compartment
1

Compartment
2

Compartment
1

Compartment
2

Compartment
3

Compartment
1

Compartment
2

Figure 6.3 Schematic representations of one-, two-, and three-compartment models.

iv Dose,
A 0

Central
compartment
volume = Vd

k e

10 100

y-intercept = C 0 = A 0 /Vd

8

10

slope = -k e /2.303

6

C(t)

1

1/2 C(t)

4

0.1

2 t 1/2

0

0.01

Time Time

Figure 6.4 Representation of a one-compartment model with iv administration and first-order elimi-
nation, including a typical plasma concentration vs. time profile (linear and logarithmic scales). The
volume of distribution, elimination rate constant, and elimination half-life are estimated by graphical
methods.