Biology Reference
In-Depth Information
.  MAterIAl dePoSItIon on the eXterIor And InterIor 
SurFACe oF tMV
The versatility of TMV as a biotemplate for fabrication of a range of
nanotubular inorganic materials via metal deposition has been demonstrated.
Nucleation of materials can be achieved on the exterior surface, as well as
in the central 4 nm-wide channel. The exterior and interior are chemically
distinct, and the different amino acids on the exterior and interior can be
regarded as nucleation sites. Amino acid side chains on the interior surface
are predominantly carboxylic acids from Asp and Glu; hence, the interior
is negatively charged under physiological conditions. The exterior surface
Figure
Transmission electron microscopy (TEM) images of mineralized
TMV structures. (A) CdS-mineralized TMV particles. Scale bar = 50 nm. Inset:
corresponding EDX spectrum (Ni and Cu peaks arise from TEM grid and specimen
holder, respectively). (b) TEM micrograph showing heavily mineralized PbS/TMV
nanotube composite; scale bar = 50 nm. Inset: high-resolution lattice image of a
single-domain PbS nanocrystal associated with the TMV external surface. (c) Self-
assembled silica/TMV nanotubular superstructure. The white arrows mark the ends
of five individual TMV particles, each 300 nm in length, that have aggregated end to
end along with a thin external shell of amorphous silica. Inset: corresponding EDX
spectrum showing Si peak (Cu peaks are from TEM grid). (d) TEM images of iron-
oxide-coated TMV rods. Reproduced with permission from Shenton, W., Douglas, T.,
Young, M., Stubbs, G., and Mann, S. (1999) Inorganic-organic nanotube composites
from template mineralization of
6.5
Tobacco mosaic virus
,
Adv. Mater.
,
11
, 253-256.
 
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