Biomedical Engineering Reference
In-Depth Information
Flory-Rehner model is an excellent starting point, more recent theoretical
advancements must be considered. The limitations of the mathematical models
are numerous, but an extensive literature on model networks may aid in the
design of experiments and analysis of the results. In particular, the use of scaling
laws may allow predictions of swelling and mechanical properties based on prior
results. The introduction of peptides into the backbone of the polymers has to
date not presented obstacles to the analysis of the thermodynamics of swelling as
polymer networks. Given the compact nature of proteins and the small size of
peptides, this approach may prove to be reasonable. The measurements required
for the calculation of network properties, i.e. swelling and/or stiffness, are
typically already performed in characterizing hybrid hydrogels. Thus, a more
detailed analysis of hybrid hydrogels may allow true engineering of the
properties of these promising materials.
References
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