BIOMIMETIC MATERIALS FOR ENGINEERING OF NEURAL TISSUES: CONTROL OF CELL ADHESION AND GUIDING NEURAL CELL OUTGROWTH WITH PEPTIDE-CONJUGATED POLYMER STRUCTURES - Biologically-Responsive Hybrid Biomaterials - page 341

Table 1. Selected peptide sequences and effects on the nervous system.

Peptide sequence Outcomes Reference

Hippocampal cell
adhesion

IKVAV [20]

Increased hippocampal
neurite length
Neuroblastoma cell
adhesion

YIGSR [20], [21]

GDPGYIGSR/GQAASIKVAV
(50:50)

DRG neurite outgrowth [22]

Increased neurite
length on hippocampal
cells

GGGGGGYIGSR or
GGGGGGIKVAV

[20]

Supports neuron
adhesion
Encouraged axonal
ingrowth at lower dosage
levels.
Supports Schwann
and glial cell
adhesion

[17], [61]
[23]

RGD, GRGDS

DRG increased neurite
outgrowth

CDPGYIGSR [24]

DRG adhesion and
neurite outgrowth

CQAASIKVAV [25]

Adhesion of astrocytes
but not fibroblasts

KHIFSDDSSE [26]

RNIAEIIKDI Neurite Extension [27]

Return of optic nerve
function after injury

RADA16 [28]

CDPGYIGSR or
CSRARKQAASIKVAVSAD

Improved PNS
regeneration in rats

[29]