Biomedical Engineering Reference
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Fig. 1. Architecture and composition of a stem cell niche: Adult stem cells are located within
instructive microenvironments comprised of complex mixtures of extracellular cues delivered by
support cells in close proximity (a). The main components of a niche are support cells and their
secreted transmembrane cell-cell adhesion proteins, soluble factors and the surrounding
extracellular matrix (b). Reproduced with permission from
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. Copyright 2009 Wiley InterScience.
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