Biomedical Engineering Reference
In-Depth Information
S
S
S
S
OH
K
K
HO
A
P
G
O
R =
K
K
Tn epitope
HO
P
K
AcHN
G
R
R
39
O
O
ONH
2
R
R
O
N
N
O
N
O
N
O
O
R
R
O
O
O
O
R
R
K
K
N
N
O
N
O
N
G
A
P
O
O
K
K
P
K
G
O
O
K
K
G
A
P
O
X
K
K
P
K
G
NH
2
41
K-L-F-A-V-W-K-I-T-Y-K-D-T
38
: X =
O
N
NH
2
PV peptide
S
O
O
S
N
S
S
NO
2
40
: X =
pal-S-I-I-N-F-E-K-L-a-K-Cha-V-A-A-W-T-L-K-A-A-a-Ahx
NH
2
O
CD8+ T-cell e pitop e
(OV A
257- 264
)
Adjuvant
(pa lmitic acid)
CD4+ T-cell e pitop e
(PADRE)
N
Fig. 15. Multi-epitopic anticancer synthetic vaccines based on cyclodecapeptide scaffold.
showed a strong production of antibodies that recognized human tumor cell lines
and stimulation of T-cells without administration of an external adjuvant. More
interestingly, an improved survival and a significant reduction of tumor size
in mice inoculated with MO5 carcinoma cells were also observed, suggesting
the promising potential of four-component vaccine prototypes for human
immunotherapy against cancers. It should be noted that similar cyclic
glycopeptide models were used as multi-epitopic scaffolds for the preparation of
vaccine against HIV using either click chemistry [77] or Lansbury aspartylation
[78] for the attachment of carbohydrate epitope, which strengthens the interest of
cyclopeptide scaffolds as tool for immunotherapy.
4.3.
Other multivalent scaffolds
Other diverse other multivalent scaffolds were also described and have shown
interesting potential for an immunological purpose. For example a
poly(aminoamine) dendrimer was decorated with 4 to 32 copies of the
carbohydrate TF antigen as breast cancer marker by amide coupling [79] or
Search WWH ::
Custom Search