Biomedical Engineering Reference
In-Depth Information
TABLE 14.2
Lobe Volumes: in cc
3
(mean
sd). Only
Temporal (Left Larger Than Right) and
Parietal (Left Smaller Than Right) Lobe
Volume Differences are Significant (
p
0.05)
Left
Mean(sd)
Right
Mean(sd)
Lobe
Frontal
175.0(25.3)
174.0(25.0)
Temporal
119.3(18.1)
109.8(16.4)
Parietal
95.0(13.7)
99.3(14.3)
Occipital
44.8(7.9)
45.9(8.2)
FIGURE 14.9
3D renderings of structure SPAMs, automatically generated from (top) 152 healthy adults
(age 24.6
3.6). From left to
right: top view, lateral view of left hemisphere, medial view of right hemisphere.
4.8) and (bottom) 110 children and adolescents (age 11.2
and inferior occipital gyrus (left larger than right). The left-right volume dif-
ference for temporal (left larger than right) and parietal (left smaller than
right) lobes are significant at the
p
0.05 level (see Table 14.2). The method
presented here is completely automatic, fully objective, and has been applied
to a large ensemble of brain volumes. The resulting volume statistics will
prove useful as a normative data base for comparisons in future studies of nor-
mal or pathological brains. Figure 14.9 compares the average segmentations
of the ICBM young adult brains with the child
adolescent MRI data base.
14.3.3
Analysis of Normal Anatomical Variability
Besides segmentation, ANIMAL has been applied to nonrigid registration and
to the analysis of morphometric variability. To quantify anatomical variability, it
is necessary to identify homologous features between the source and target
volumes and to measure the difference in position between them, within the
