Biomedical Engineering Reference
In-Depth Information
14
Use of Regis
tration for Cohort Studies
D. Louis Collins, Alex P. Zijdenbos, Tomás Paus, and Alan C. Evans
CONTENTS
14.1 Introduction.............................................................................................. 303
14.2 Technical Issues........................................................................................ 305
14.2.1 The Reference Space ................................................................. 306
14.2.1.1 Talairach Stereotaxic Space .................................... 306
14.2.1.2 MNI Stereotaxic Space ............................................ 308
14.2.2 The Spatial Mapping Function................................................ 309
14.2.3 The Similarity Measure ............................................................ 310
14.2.4 The Optimization Procedure ................................................... 310
14.2.5 Other Brain-Based Reference Spaces...................................... 311
14.3 Applications ............................................................................................. 312
14.3.1 Registration-Based Analysis of Normal
Brain Anatomy........................................................................... 313
14.3.2 Segmentation-Based Analysis of Normal
Brain Anatomy........................................................................... 317
14.3.3 Analysis of Normal Anatomical Variability .......................... 319
14.3.4 Analysis of Brain Anatomy in Multiple Sclerosis................. 321
14.3.5 Analysis of Brain Metabolism in Multiple Sclerosis ............ 322
14.4 Conclusion ................................................................................................ 323
References ............................................................................................. 323
14.1
Introduction
The past ten years, known as the
have been marked by
advances in medical tomographic imaging technology that have made it
possible to acquire highly detailed volumes of human anatomy in three
dimensions (3D) with magnetic resonance imaging (MRI). Such technol-
ogy has facilitated the explosion of human brain mapping research,
where anatomical MRI is combined with positron emission tomography
decade of the brain,
