Biomedical Engineering Reference
In-Depth Information
Ventricles
30
20
10
0
0
4
8
12
16
Time (months)
Squares = Alzheimers
Circles = Controls
FIGURE 7.28
Alzheimer's disease: Plot of percentage change in ventricular size for patients with Alz-
heimer's Disease (squares) and normal controls (circles). The patients show a greater increase
in ventricular volume than controls.
Another three patients showed evidence of brain swelling, two studies were
equivocal, and one was negative. These changes may reflect difference
phases of the first episode of this illness.
24,25
7.16 Alzheimer's Disease
Fox, Freeborough, and Rosser
5,26,27
have used registration, subtraction,
and quantification to demonstrate atrophic changes in Alzheimer's dis-
ease. They found marked changes compared with controls (Figure 7.28).
Some pre-symptomatic patients also had early changes detectable with
registration and quantification.
7.17
Postoperative Changes
Although three published serial studies of the brain following coronary
artery bypass surgery (CABS) have been negative except in patients who had
clinical evidence of strokes, registration of serial scans has shown abnormal-
ities in most patients studied to date.
28
