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The main argument of the raft concept is that membrane lipids form
dynamic microdomains that play key roles in membrane functions.
Increasing evidence supports this concept of lipid rafts. Several studies
have proposed the existence of other lipid microdomains with differ-
ent properties from the classical rafts. 49-51 Lines of evidence have been
accumulating that many viruses (probably most enveloped viruses)
replicate in a way that depends on the functions of these lipid micro-
domains. A better understanding of the behavior of these micro-
domains may provide new insights that are generally applicable for
virus replication in cells, and offer the possibility of new strategies for
counteracting the artful viruses.
Acknowledgments
I thank Dr. R. A. Lamb for kind suggestion. I also thank Drs. Y. Yanagi
and A. P. Schmitt for their critical reading and helpful comments.
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