Biology Reference
In-Depth Information
Host Cell Recognition and Entry
Class I major histocompatibility complex proteins have appeared to
be the major cell surface receptors for SV40 (Fig. 5).
32,33
The class I
molecules encoded by the major histocompatibility complex (MHC)
SV40
MHC class I
GM1
Gal
E330K (site 1)
GalNAc
SA
Gal
Glc
Endocytosis
Caveosome
E157K (site 2)
Endoplasmic Reticulum
SV40 particle
VP1-pentamer-VP2 or VP3
complex
minichromosome
Particle assembly (site 1, 2)
Fig. 5.
Schematic reproduction of SV40 calcium binding site mutant parti-
cle phenotype in virus infectious pathway. E330K site 1 calcium binding site
mutant is deficient in the host cell attachment and endocytosis. Another
E157K site 2 calcium binding site mutant is deficient in virus genome trans-
fer into nucleus inside host cell.
