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Fig. 3.
-barrel domain
structure within the VP34 capsid protein of HAstV and three structure-based
sequence alignments of HAstV sequence with capsid proteins from other
viruses: VP2 coat protein of Theiler's murine encephalomyelitis virus (Protein
Data Bank 1TMF), small subunit of Bean pod mottle virus coat protein
(Protein Data Bank 1PGL), and coat protein (shell domain) of Carnation mot-
tle virus (Protein Data Bank 1OPO). E-value is the measure of confidence in
prediction of the 3D-PSSM alignment. Beta-barrel domains are indicated by
boxes, beta-strands are indicated in bold, and underlined sequences correspond
to alpha-helices. RB denotes the putative RNA binding domain. Amino acid
(aa) positions refer to HAstV-1 Oxford reference strain (accession no. L23513).
Schematic representation of the predicted eight
β
HAstV Virus-like Particles (VLPs)
Recently, it has been demonstrated that expression of the complete
ORF2 of HAstV serotypes 1 and 2 leads to the formation of VLPs
using the baculovirus and vaccinia virus recombinant expression
systems, respectively. 25,27 Using the baculovirus system, VLPs can be
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