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regard to assembly, infection, replication, and pathogenesis. Future
structural studies, particularly those at or near atomic resolution, will
be essential to deciphering the mechanism of herpesvirus assembly
and maturation, and will ultimately aid in developing therapeutic
strategies for anti-herpes interventions.
Acknowledgments
We thank Ms. Xiaorui Zhang for graphical illustration and editorial assis-
tance. The research described here was supported in part by grants from
the National Institutes of Health (AI069015, CA094809, GM071940),
the March of Dimes Birth Defects Foundation (5-FY99-852), the
American Heart Association (0240216N), and the Welch Foundation.
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