Biology Reference
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Fig. 2.
Maturation of the HSV-1 capsid. (
a
) Protease-knockout mutant
m100, temperature-sensitive mutant tsProtA, and
in vitro
-assembled pro-
capsid all have a similar structure, which is more porous and spherical than
that of the wild-type A capsid. (
b
) Capsid maturation is a continuous process
with numerous intermediate steps (shown in chronological order from top
to bottom). (
c
) Percentage of particles at various steps of maturation at
given times. Adapted with permissions from the publishers and authors.
21,22
Fig. 1. These tegumented capsids acquire their outer tegument layer
proteins and envelope by budding into the
trans-
Golgi network.
31
In addition to electron micrographs showing capsids (presumably with
a layer of inner tegument proteins) in the cytoplasm, Skepper
et al.
found that the phospholipid composition of secreted virions is differ-
ent from that of virions in the perinuclear space and that the HSV-1
